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Cephalexin

Systems	General (Systemic)
Category	First Generation Cephalosporin

Pharmacokinetics

Cephalexin is partially protein bound, attains high concentration in bile and is excreted in urine as such.Plasma half life is 60 minutes.

Indications

Cephalexin is used in respiratory tract infections, sinusitis, otitis, soft tissue infections, UTI and biliary tract infections.It is active against streptococci, gonococci, meningococci, corynebacterium.diphtheria, clostiridia and actinomyces. It is less active against penicillinase producing staphylococci and H.influenza.

Routes of Administration and Dosage

Cephalexin-Oral : 0.25-1 gram 6-8 hourly[children 25-100mgs/kg/day].

Contra Indications

Cephalexin is contraindicated in hypersensitivity to cephalosporins.

Precautions

Special precaution to be taken in patients who are hypersensitive to penicillins, pseudomembranous collitis, pregnancy, lactation and renal failure.

Interactions

Few interactions have been reported.

Brand Names

Alcephin (Alembic), Alexin (Dabur), Alsporin(Dominion), Betaspore(Aristo), Blucef(Blue cross), Cefadyl(Unique), Cefalex(PCI), Cefalin(Euphoric), Cefamax(Max), Ceff(Lupin), CefKap(Gland Pharma), Cephaxin(Biochem), itaceph(Citadel), Faxin(Alpine), Felopen(Plethico), Hycef(Grandix), LX-500(Apex), Mafexin(Malladi Drugs), Nufex(Searle), Oceph(Emcure), Oriphex(Alidac), Phexin (Glaxco Pharma), Prilex(Hindustan), Rakcef(Rallis), Rofex(Rhone Pic), Safexin (Saga Labs), Sepexin(Lyka), Solexin Kid(SOL), Sporen(Dey's), Sporidex(Ranbaxy), Winphex Distab (Wings Pharma).