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Famotidine

Systems	Gastro-Intestinal System
Category	H2-receptor antagonist

Pharmacokinetics

It is well absorbed orally, but its bioavailablity is reduced when given with antacids. Theraupetic effect lasts for about 5-8 hours. It is excreted mainly in the urine, within 24 hours mainly as unchanged drug. It can cross the placental barrier and is secreted in milk.

Indications

Famotidine belongs to the class H2-receptor antagonists.They are used to treat duodenal ulcers and prevent their recurrence,gastric ulcers and in Zollinger-Ellison syndrome .

Routes of Administration and Dosage

40 mgs at bed time or 20 mg b. d

Contra Indications

Famotidine is contraindicated in : Renal disease. In Hepatic disease: the level of famotidine may build up in the bloodstream, which increases the risk of adverse effects.

Precautions

Special precautions to be taken in pregnancy, lactation and in children .

Interactions

Famotidine may decrease the effects of itraconazole or ketoconazole, hence famotidine should be taken at least 2 hours after these drugs.

Brand Names

Acilo (Wander), Acipep (Kramer), Acredin (Sarabhai), Advantac (Win-Medicare), Autidine (Aurobindo Pharma), Axid (Saga Labs), Blocacid (IPCA), Facid (Intas), Fadine (Aristo), Famocid (Sun Pharma), Famonite (Alidac), Famopril (Recon), Famorila (Glenmark), Famotin (USV), Famovane (JK Ind), Famowal (Wallace), Fampep (Seagull), Famtac (Nicholas-Piramal), Febcid (Brown & Burk), Fudone (Wockhardt), Noctin (PCI), Norfam (Medicamen), Pepgard (Rallis), Recid (Max), Tobur (Themis Pharma), Topcid (Torrent), Ulcimax (Protec), Zactane (Wyeth Lederle)